Visit SIGMA
Book Appointment
Request Remote Opinion
Book Appointment

Regenerate. Restore. Return to Performance.

At SIGMA Orthopedics, we don’t just mask knee pain — we rebuild function through precision-guided biologic treatments engineered from your own healing cells.

Discover SynerG™ — a proprietary, three-ingredient solution designed to reduce inflammation, protect cartilage, and accelerate recovery.

Schedule Your SynerG Consultation
Download Patient Guide

Most “regenerative” clinics offer PRP or stem cells as one-size-fits-all solutions.

At SIGMA, we know joint pain is multi-factorial — inflammation, enzyme damage, and tissue loss all work together to degrade the joint.
That’s why SynerG™ combines three biologic components — PRP, A2M, and Bone Marrow Concentrate — each targeting a specific part of the degenerative cascade.

A New Standard in Knee Preservation

SynerG™ is a three-layer biologic treatment system designed to protect cartilage, reduce inflammation, and stimulate tissue regeneration — using your own biologic cell signaling system.
If you’re an active person whose knee still bothers you — despite cortisone shots, PT, or single-injection biologics — you’re not alone. Most clinics treat only one piece of the puzzle. SynerG was built for the performance-minded person who won’t accept “just okay.” It’s your 3-step biologic protocol: Protect → Prime → Repair. Engineered using precision, measurement, and elite surgical science.
The SynerG Three-Layer Approach:
Layer
Purpose
1. Protect
Blocks the destructive enzymes degrading cartilage (via A2M). Without this, your knee keeps sliding backward even if you feel “better.
2. Prime
High-dose PRP (6–10× concentration) creates an anti-inflammatory, healing environment.
3. Repair
Bone-marrow-derived concentrate delivers regenerative cells to rebuild tissue — performed under ultrasound/fluoro guidance by a surgeon.

Component

Job

PRP

Growth + repair signals

A2M

Blocks cartilage-destroying enzymes

Protease Inhibitors

Reduce inflammation at the molecular level

BMAC Stem Cells

Regenerate tissue + support scaffold healing

Who It’s For

  • Active adults with early to moderate knee arthritis
  • Athletes with cartilage or meniscus injury seeking to avoid surgery
  • Patients who’ve had cortisone or hyaluronic acid injections with limited relief
  • Individuals not ready for joint replacement
If you still have some cartilage remaining, you’re often an ideal candidate for biologic joint preservation.
Take the 2-minute candidacy quiz

“Why Not Just Get PRP or Stem Cells Alone?”

Performed in a sterile orthopedic environment — not a “stem cell clinic”

SynerG™ was developed for orthopedic patients who demand evidence-based precision, not guesswork.
It’s performed in a clinical orthopedic environment using fluoroscopic or ultrasound guidance, ensuring exact placement and maximum efficacy — not just a “shot in the dark.”
Unlike stand-alone PRP or stem cell treatments, SynerG™ addresses the entire degenerative process, not just inflammation.

WHY PATIENTS NEED SYNERG

Why Conventional Therapies Fail — and How SynerG Fixes It.

Most patients are stuck in the “treatment gap”:

Traditional injection therapies are designed to temporarily reduce pain. SynerG™ is built to change the joint environment itself — blocking enzymes, restoring balance, and stimulating healing at the cellular level.

Why SynerG™ Outperforms Conventional Injections

Feature

Cortisone

PRP

SynerG™

Addresses root cause

❌

⚠️

✅

Protects cartilage

❌

⚠️

✅

Regenerates tissue

❌

⚠️

✅

Image-guided precision

⚠️

⚠️

✅

Part of 100-Day program

❌

❌

✅

WHY PATIENTS CHOOSE SYNERG

Transparent, all-inclusive pricing — no surprise add-ons

Most biologic clinics charge separately for each part of treatment:
The SynerG Bundled Package Includes ALL

Done in a sterile orthopedic medical center — not a stem cell clinic
✔ Performed by a Harvard-trained sports medicine surgeon
✔ Guided by ultrasound + fluoroscopic precision, not blind injections
✔ Outcomes tracked through the SIGMA Scoreboard™ using PROMs and imaging
✔ Return-to-activity plan built into the 100 Days to Health™ program
✔ No opioids, no steroids, no downtime surgery

AdobeStock 143102352 3
Patients choose SynerG™ because it’s not a quick fix — it’s a precision-guided recovery journey. From pre-procedure planning through your 100-day follow-up, every step is monitored and measured to ensure lasting improvement. You’ll have direct access to your SIGMA clinical team, guided rehabilitation, and transparent data on your progress.
Start My 100-Day Recovery Plan
“Avoided surgery and got my life back.”
“I was told I needed knee surgery or to ‘just live with the pain.’ Dr. McCormick evaluated me and recommended the SynerG protocol instead. Within 3 months, I was walking stairs without limping and back to the gym. I loved that everything was ultrasound-guided and based on real data, not guesswork.”
— Mark R., 52, Former Marathon Runner
““Professional, scientific, and results-driven.”
“I had PRP at another clinic years ago and it didn’t help much. I didn’t realize the missing piece was the combination of A2M + PRP + stem cells + protease inhibitors. The SynerG approach made sense, and the experience felt like real medicine — not a sales pitch. My shoulder pain is now 80% better and still improving.”
— Laura S., 44, Active Tennis Player
““Back to work without downtime.”
“As a contractor, I couldn’t afford a long recovery. The SynerG injection was done in a sterile orthopedic room, took under an hour, and I was back on light duty the next day. The transparency in pricing and follow-up calls impressed me more than anything.”
— Daniel P., 38, Construction Supervisor
“I wanted a real medical solution, not a ‘stem cell clinic."
“I was skeptical until I saw that everything was done by a Harvard-trained orthopedic surgeon and backed by outcome tracking. No gimmicks, no upsells. Just science. My hip pain went from daily discomfort to almost gone — without pills or surgery.”
— Cynthia W., 60,Retired Nurse & Pickleball Player
“Data-driven care that actually feels personalized.”
“The best part wasn’t just the injection — it was the way the SynerG team tracked my progress through follow-up visits, ultrasound imaging, and the SIGMA Scoreboard app. I felt like a partner in my treatment, not a number on a schedule.”
— Alex G., 31,Firefighter & CrossFit Athlete

WHAT THE APPOINTMENT INCLUDES

Every SynerG™ appointment is more than just an injection — it’s a full orthopedic assessment and treatment experience.

✅ Personalized evaluation by a Harvard-trained orthopedic surgeon
✅ Image-guided joint mapping and diagnostic ultrasound
✅ SynerG™ biologic preparation (PRP + A2M + BMAC)
✅ Precision-guided injection under ultrasound or fluoroscopy
✅ Enrollment into 100-Days-to-Success™ rehabilitation tracking

Transparent, all-inclusive pricing. No hidden fees. No upcharges.
Schedule Your SynerG Consultation

COST & VALUE

SynerG™ is a physician-delivered, lab-grade procedure using advanced biologic processing systems — not a spa-based injection. Our transparent pricing includes evaluation, procedure, biologic preparation, and follow-up — ensuring quality without surprises.

Transparent, all-inclusive pricing — no surprise add-ons

Most biologic clinics charge separately for each part of treatment:
  • All biologic materials included
  • Image-guided precision injections
  • Outcome tracking + 100-day follow-up protocol
  • No surprise fees, no add-on charges

Early Access Program Pricing Range:
$2,500 – $2,750 (final price depends on customized biologic plan)
(Financing available. HSA/FSA accepted. LOP and PI cases eligible.)

Treatment in NYC Market

Typical Price

PRP injection

$800 – $1,500

BMAC / “stem cell” injection

$3,000 – $7,500

A2M injection

$1,000 – $2,000

Surgeon evaluation + imaging review

$300 – $600

Facility + anesthesia + guided procedure

$1,500 – $3,000

Process Steps

Step 01

Comprehensive evaluation + imaging review

Step 02

Same-day or scheduled biologic harvest & injection

Step 03

Walk-out same day, no anesthesia, no brace

Step 04

100 Days to Health™ recovery plan with milestone tracking via the SIGMA Scoreboard™

FREQUENTLY ASKED QUESTIONS

Results typically last 12–18 months, depending on your activity and joint health.

Yes, SynerG uses components and processes that meet FDA safety standards.

Minimal—most patients return to light activity within a day.

Yes, after your provider clears you, usually within a few weeks.

You may still qualify; SynerG can complement prior regenerative treatments.

Schedule a consultation to review your condition, imaging, and goals.

SynerG™ is performed exclusively by orthopedic surgeons using image guidance and real biologic science — not marketing hype. Our outcomes are measured through data, not anecdotes.
Meet Dr. Frank Mccormick, MD
SIGMA ORTHOPEDIC MD
Let's Connect!